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KMID : 1197720210140020153
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대한파킨슨병 및 이상운동질환 학회지
2021 Volume.14 No. 2 p.153 ~ p.156
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Myoclonus-Ataxia Syndrome Associated with COVID-19
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Shetty Kuldeep
Jadhav Atul Manchakrao
Jayanthakumar Ranjith
Jamwal Seema
Shanubhogue Tejaswini
Reddy Mallepalli Prabhakar
Dash Gopal Krishna
Manohar Radhika
Philip Vivek Jacob
Huded Vikram
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Abstract
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Neurological manifestations of coronavirus disease (COVID-19) have increasingly been reported since the onset of the pandemic. Herein, we report a relatively new presentation. A patient in the convalescence period following a febrile illness with lower respiratory tract infection (fever, myalgia, nonproductive cough) presented with generalized disabling myoclonus, which is phenotypically suggestive of brainstem origin, along with additional truncal cerebellar ataxia. His neurology work-ups, such as brain MRI, electroencephalography, serum autoimmune and paraneoplastic antibody testing, were normal. His CT chest scan revealed right lower lung infiltrates, and serological and other laboratory testing did not show evidence of active infection. COVID-19 titers turned out to be strongly positive, suggestive of post-COVID-19 lung sequelae. He responded partially to antimyoclonic drugs and fully to a course of steroids, suggesting a para- or postinfectious immune-mediated pathophysiology. Myoclonusataxia syndrome appears to be a neurological manifestation of COVID-19 infection, and knowledge regarding this phenomenon should be increased among clinicians for better patient care in a pandemic situation.
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KEYWORD
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COVID-19, Myoclonus, Gait ataxia
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